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Journal of the American Animal Hospital Association 41:98-103 (2005)
© 2005 American Animal Hospital Association

Evaluation of Extended-Release Diltiazem Once Daily for Cats With Hypertrophic Cardiomyopathy

Michelle Wall, DVM, Diplomate ACVIM, Clay A. Calvert, DVM, Diplomate ACVIM, Sherry L. Sanderson, DVM, PhD, Diplomate ACVIM, Diplomate ACVN, Andrea Leonhardt, BS, LVT, Corrie Barker, DVM, Diplomate ACVIM and Tiffany K. Fallaw, BS

From the Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens, Georgia 30602.

Serum diltiazem concentrations were evaluated following either 30 mg or 60 mg of an extended-release diltiazem administered orally once daily to 13 cats. Sequential blood samples were obtained over 24 hours. Both dosages usually resulted in elevated serum concentrations of >200 ng/mL at 6, 12, 18, and 24 hours. The 30-mg dosage was sometimes associated with low serum concentrations of <50 ng/mL at 18 and 24 hours. The 60-mg dosage (9.3 to 14.8 mg/kg) was associated with lethargy, gastrointestinal disturbances, and weight loss in nine (36%) of 25 client-owned cats. Gastrointestinal disturbances were recognized within 1 week, and weight loss was detected after 2 to 6 months of treatment.






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